Efficacy, safety and long-lasting results

Efficacy
In RESTYLANE™, the overall NASHA
gel concentration is 20 mg/ml stabilized HA. This concentration has
been carefully
selected to provide optimal maintenance of volume for tissue augmentation
and lifting. An important advantage of the non-animal stabilized hyaluronic
acid
used in other related products is its prolonged residence time in the tissues.
However, NASHA, like other biodegradable implants, is slowly broken down
after injection. With conventional biodegradable implants, this has the disadvantage
that the implant progressively shrinks and the esthetic benefit therefore
quickly
diminishes. Uniquely, with NASHA products the slow biodegradation
of the stabilized HA does not lead to gradual shrinkage. As the NASHA is
degraded, each molecule progressivly binds more water, more free water binding
sites
per molecule. This process is called isovolemic degradation. Thus, with the
implants, volume is maintained until the stabilized gel is almost completely
degraded. When the gel is completely degraded, the remaining HA fragments
are
metabolized together with the natural tissue HA, and no trace of the original
implant remains.

RESTYLANE™ is isovolemically degraded. This means that it can hold
more water the less concentrated it is.
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